InstaDeepAI/winnow-helaqc-model

Winnow recalibrates confidence scores and provides FDR control for de novo peptide sequencing (DNS) workflows. This repository hosts a pretrained, general-purpose calibrator that maps raw InstaNovo model confidences and complementary features (mass error, retention time, beam features, fragment…

# InstaNovo: De novo Peptide Sequencing Model ## Model Description

# InstaNovo: De novo Peptide Sequencing Model ## Model Description

InstaNovo-P is a specialized transformer-based model for de novo peptide sequencing from phosphoproteomics mass spectrometry data. This model is specifically trained and optimized for identifying phosphorylated peptides and their modification sites.

InstaNovoPlus is a diffusion-based model for de novo peptide sequencing from mass spectrometry data. This model leverages multinomial diffusion for accurate, database-free peptide identification for large-scale proteomics experiments.

This package wraps the functionality of the Thermo Fisher Scientic RawFileReader .NET 8.0 assembly. Within the R environment, spectra and chromatograms are represented by S3 objects. The package provides basic functions to download and install the required third-party libraries. The package is developed, tested, and used at the Functional Genomics Center Zurich, Switzerland.