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# Instruction For more information, visit our GitHub repository: https://github.com/medfound/medfound

This repository contains GGUF files for gemma4-12b-bioinfo, a fine-tuned Gemma 4 12B model for bioinformatics and computational biology.

gemma4-12b-bioinfo is a fine-tuned Gemma 4 12B instruction model for bioinformatics, genomics, and computational biology question answering.

*GenerRNA is a generative pre-trained language model for de novo RNA sequence design. It is a Transformer (decoder-only, GPT-style) model that learns the "language" of RNA from millions of natural sequences and can generate novel, realistic RNA sequences without any structural input, functional…

Aryabhata 2 is a reasoning-focused language model developed by PhysicsWallah for competitive STEM examinations (JEE, NEET). It is obtained by post-training GPT-OSS-20B via reinforcement learning on a curated curriculum of Physics, Chemistry, Mathematics, and General Reasoning questions — achieving…

> VIDRAFT FINAL-Bench — chemistry-specialized 218B MoE, served via the DELPHI 5-Phase inference cascade.

HealthJudge is a domain-adapted helpfulness evaluator for health-related Community Notes. It is designed to judge whether a note provides helpful context for a potentially misleading social-media post, following the Community Notes helpfulness criteria.

ProtGPT3-MSA is a multiple-sequence, homolog-conditioned autoregressive protein language model. It is part of the ProtGPT3 family, an open-source suite of promptable and aligned protein language models for protein sequence generation.

GGUF quantizations of HuggingFaceBio/Carbon-3B — a generative DNA foundation model — for efficient inference with llama.cpp.

Target-Conditioned Molecular Ideation Model for Drug Discovery Research

Genos-m is a foundation model for human-associated microbial genomes. It is trained to model microbial DNA sequences at single-nucleotide resolution and supports ultra-long genomic contexts up to one million tokens.

Qwen3-8B-syco_med-gated-attention-FT is a plug-and-play gated attention weight released for AI safety research.

Apertus-8B-MeditronFO is a 8B-parameter medical specialist LLM, produced by supervised fine-tuning of Apertus-8B-Instruct on the Fully Open Meditron Corpus.

Apertus-70B-MeditronFO is a 70B-parameter medical specialist LLM, produced by supervised fine-tuning of Apertus-70B-Instruct on the Fully Open Meditron Corpus.

LoRA fine-tune of Qwen3.5-9B on synthetic clinical triage Q&A pairs generated from PubMed Central open-access papers. The model is specialized for emergency-medicine decision-making: triaging patients, applying clinical decision rules, and generating protocol-grounded triage recommendations.

Base model: google/gemma-4-26b-it Architecture: MoE — 26B total / ≈4B active parameters (1 shared expert + 8 routed from a pool of 128 per MoE layer, 30 MoE layers) Method: Activation-directed expert surgery — 128 → 64 experts per layer (50% reduction) Quantization: Q4KM (≈9.7 GB on disk) Tags:…

Base model: google/gemma-4-26b-it Architecture: MoE — 26B total / ≈4B active parameters (1 shared expert + 8 routed from a pool of 128 per MoE layer, 30 MoE layers) Method: Activation-directed expert surgery — 128 → 64 experts per layer (50% reduction) Quantization: Q4KM (≈9.7 GB on disk) Tags:…

Gemma 4 E2B fine-tuned on 225K drug–target pairs for novel small-molecule generation.

## Important Notice If you are using GENERator for sequence generation, please ensure that the length of each input sequence is a multiple of 6. This can be achieved by either: 1. Padding the sequence on the left with 'A' (left padding); 2. Truncating the sequence from the left (left truncation).

MedPsy-4B is a state-of-the-art, text-only medical and healthcare language model purpose-built for edge deployment. Built on top of Qwen3-4B-Thinking-2507 and post-trained with a multi-stage pipeline (supervised fine-tuning + reinforcement learning) on curated medical data, it surpasses models…

InstaNovo-P is a specialized transformer-based model for de novo peptide sequencing from phosphoproteomics mass spectrometry data. This model is specifically trained and optimized for identifying phosphorylated peptides and their modification sites.

# InstaNovo: De novo Peptide Sequencing Model ## Model Description

# InstaNovo: De novo Peptide Sequencing Model ## Model Description

A domain-optimized reasoning model built on DeepSeek-R1-Distill-Qwen-32B, refined through a multi-stage pipeline of GPTQ quantization-aware training and QLoRA fine-tuning. Achieves 84% on MedQA — within 4 points of GPT-4o — in a ~20GB package that fits on a single L40/L40s GPU.

Duchifat-2.3-Instruct is a state-of-the-art, instruction-tuned Large Language Model developed by TopAI. As the flagship of the Duchifat series, this model represents a fundamental breakthrough in how Hebrew is processed, reasoned, and generated in the LLM era.

Fine-tuned version of google/gemma-4-E4B-it across three professional domains — Medical, Legal, and Finance — using QLoRA (4-bit NF4) with Optuna-tuned hyperparameters, trained on Kaggle T4 GPU.

L1 (Learning Unit 1) is the first language model from Lunit and Lunit Consortium, purpose-built for the medical domain. Derived from Gravity-16B-A3B-Base, L1 is designed for clinical reasoning and decision support.

# or·a·cle /ˈôrəkəl/ — a source of wise counsel; one who provides authoritative knowledge. From Latin ōrāculum, meaning divine announcement. In computer science, an oracle is a black box that always returns the correct answer — you don't ask it how it knows, you ask and it answers.

A compact protein language model distilled from ProtGPT2 using complementary-regularizer distillation---a method that combines uncertainty-aware position weighting with calibration-aware label smoothing to achieve 31% better perplexity than standard knowledge distillation at 3.8x compression.

A compact protein language model distilled from ProtGPT2 using complementary-regularizer distillation---a method that combines uncertainty-aware position weighting with calibration-aware label smoothing to achieve 54% better perplexity than standard knowledge distillation at 9.4x compression.

A compact protein language model distilled from ProtGPT2 using complementary-regularizer distillation---a method that combines uncertainty-aware position weighting with calibration-aware label smoothing to achieve 87% better perplexity than standard knowledge distillation at 20x compression.

From Inquiry to Decision: Building Trustworthy Medical AI

While large language models (LLMs) have achieved impressive progress, their application in scientific domains such as chemistry remains hindered by shallow domain understanding and limited reasoning capabilities. In this work, we focus on the specific field of chemistry and develop a Chemical…

ChemDFM-v2.0 is the latest non-thinking model of ChemDFM, the pioneering open-sourced dialogue foundation model for Chemistry and molecule science.

The MediPhi Model Collection comprises 7 small language models of 3.8B parameters from the base model Phi-3.5-mini-instruct specialized in the medical and clinical domains. The collection is designed in a modular fashion. Five MediPhi experts are fine-tuned on various medical corpora (i.e.

GitHub homepage: Cell2Sentence GitHub

InstaNovoPlus is a diffusion-based model for de novo peptide sequencing from mass spectrometry data. This model leverages multinomial diffusion for accurate, database-free peptide identification for large-scale proteomics experiments.

中文版说明

Neeto-1.0-8b is an openly released biomedical large language model (LLM) created by BYOL Academy to assist learners and practitioners with medical exam study, literature understanding, and structured clinical reasoning.

darkknight25/deepseek-16b-medical-GPT is a fine-tuned version of deepseek-ai/deepseek-l6b-moe-chat, optimized for medical question answering, reasoning, and clinical summarization using QLoRA and open-access healthcare datasets.

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Using llama.cpp release b5466 for quantization.

Dans-PersonalityEngine-V1.3.0-24b Dans-PersonalityEngine-V1.3.0-24b ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⢀⠀⠄⠀⡂⠀⠁⡄⢀⠁⢀⣈⡄⠌⠐⠠⠤⠄⡀⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⡄⠆⠀⢠⠀⠛⣸⣄⣶⣾⡷⡾⠘⠃⢀⠀⣴⠀⡄⠰⢆⣠⠘⠰⠀⡀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠃⠀⡋⢀⣤⡿⠟⠋⠁⠀⡠⠤⢇⠋⠀⠈⠃⢀⠀⠈⡡⠤⠀⠀⠁⢄⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠁⡂⠀⠀⣀⣔⣧⠟⠋⠀⢀⡄⠀⠪⣀⡂⢁⠛⢆⠀⠀⠀⢎⢀⠄⢡⠢⠛⠠⡀⠀⠄⠀⠀ ⠀⠀⡀⠡⢑⠌⠈⣧⣮⢾⢏⠁⠀⠀⡀⠠⠦⠈⠀⠞⠑⠁⠀⠀⢧⡄⠈⡜⠷⠒⢸⡇⠐⠇⠿⠈⣖⠂⠀…

Dans-PersonalityEngine-V1.2.0-24b ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⢀⠀⠄⠀⡂⠀⠁⡄⢀⠁⢀⣈⡄⠌⠐⠠⠤⠄⡀⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⡄⠆⠀⢠⠀⠛⣸⣄⣶⣾⡷⡾⠘⠃⢀⠀⣴⠀⡄⠰⢆⣠⠘⠰⠀⡀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠃⠀⡋⢀⣤⡿⠟⠋⠁⠀⡠⠤⢇⠋⠀⠈⠃⢀⠀⠈⡡⠤⠀⠀⠁⢄⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠁⡂⠀⠀⣀⣔⣧⠟⠋⠀⢀⡄⠀⠪⣀⡂⢁⠛⢆⠀⠀⠀⢎⢀⠄⢡⠢⠛⠠⡀⠀⠄⠀⠀ ⠀⠀⡀⠡⢑⠌⠈⣧⣮⢾⢏⠁⠀⠀⡀⠠⠦⠈⠀⠞⠑⠁⠀⠀⢧⡄⠈⡜⠷⠒⢸⡇⠐⠇⠿⠈⣖⠂⠀ ⠀⢌⠀⠤⠀⢠⣞⣾⡗⠁⠀⠈⠁⢨⡼⠀⠀⠀⢀⠀⣀⡤⣄⠄⠈⢻⡇⠀⠐⣠⠜⠑⠁⠀⣀⡔⡿⠨⡄…

GP-MoLFormer is a class of models pretrained on SMILES string representations of 0.65-1.1B molecules from ZINC and PubChem. This repository is for the model pretrained on all the unique molecules from both datasets.