InstaDeepAI/instanovo-v1.0.0

# InstaNovo: De novo Peptide Sequencing Model ## Model Description

InstaNovo-P is a specialized transformer-based model for de novo peptide sequencing from phosphoproteomics mass spectrometry data. This model is specifically trained and optimized for identifying phosphorylated peptides and their modification sites.

InstaNovoPlus is a diffusion-based model for de novo peptide sequencing from mass spectrometry data. This model leverages multinomial diffusion for accurate, database-free peptide identification for large-scale proteomics experiments.

Winnow recalibrates confidence scores and provides FDR control for de novo peptide sequencing (DNS) workflows. This repository hosts a pretrained, general-purpose calibrator that maps raw InstaNovo model confidences and complementary features (mass error, retention time, beam features, fragment…

Winnow recalibrates confidence scores and provides FDR control for de novo peptide sequencing (DNS) workflows. This repository hosts a calibrator trained on the HeLa Single Shot dataset as referenced in our paper: De novo peptide sequencing rescoring and FDR estimation with Winnow.

Tahoe-x1 is a family of perturbation-trained single-cell foundation models with up to 3 billion parameters, developed by Tahoe Therapeutics. Pretrained on 266 million single-cell transcriptomic profiles including the Tahoe-100M perturbation compendium, Tahoe-x1 achieves state-of-the-art performance…