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A directory of tools, AI models, datasets, and research resources for biotech, bioinformatics, and other scientific fields. Aggregated from curated GitHub awesome-lists, HuggingFace, bio.tools, Bioconductor, and more.
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qwen35-9b-medical is an Ollama/GGUF medical assistant profile based on Jackrong/Qwen3.5-9B-Claude-4.6-Opus-Reasoning-Distilled-v2-GGUF, distributed locally through the Ollama model kwangsuklee/Qwen3.5-9B.Q4KM-Claude-4.6-Opus-Reasoning-Distilled-v2.
As part of the ENCODE 4 Project, we trained BPNet models on 2,339 ENCODE transcription factor ChIP-seq experiments spanning 788 targets across 175 biosamples. Here, we provide all models for open-source use.
RomeroLab-Duke/prism-antibody
by RomeroLab-DukePRISM is an antibody language model that jointly predicts amino acid identity and germline/non-germline (GL/NGL) position classification, enabling developability-aware antibody sequence modeling.
the-matter-lab/clari
by the-matter-labThis repository contains data and checkpoints for the paper: Fast Organic Crystal Structure Prediction with Unit Cell Flow Matching (arXiv).
escalante-bio/jpromera
by escalante-bioJAX/Equinox parameters for Promera, a dual-purpose biomolecular generative model for structure prediction and binder design. These weights were converted module-by-module from the official PyTorch checkpoint bjing-mit/promera (promera_2606.ckpt) and validated numerically against it (per-module…
paradoxdan/nano-scGPT
by paradoxdan# nano-scGPT The simplest, fastest repository for scGPT inference, (soon) finetuning and trianing, with minimal dependencies. It reimplements the original scGPT from scratch. nanoscgpt/model.py is pure PyTorch in ~270 lines of code, and nanoscgpt/scGPT_tokenizer.py turns raw scRNA data into model…
mradermacher/Phi-4-Instruct-Bioaligned-GGUF
by mradermacherFor a convenient overview and download list, visit our model page for this model.
mradermacher/gemma4-12b-bioinfo-GGUF
by mradermacherFor a convenient overview and download list, visit our model page for this model.
# Instruction For more information, visit our GitHub repository: https://github.com/medfound/medfound
This repository contains GGUF files for gemma4-12b-bioinfo, a fine-tuned Gemma 4 12B model for bioinformatics and computational biology.
gemma4-12b-bioinfo is a fine-tuned Gemma 4 12B instruction model for bioinformatics, genomics, and computational biology question answering.
modelid = "DuanYi/R3LMHepG2"
Bioaligned/Phi-4-Instruct-Bioaligned
by BioalignedA merged (ready-to-use) version of microsoft/phi-4 fine-tuned for biological R&D reasoning via QLoRA and evaluated on the Bioalignment Benchmark.
*GenerRNA is a generative pre-trained language model for de novo RNA sequence design. It is a Transformer (decoder-only, GPT-style) model that learns the "language" of RNA from millions of natural sequences and can generate novel, realistic RNA sequences without any structural input, functional…
Wildstash/DentalGPT
by Wildstashbiohub/esm3-sm-open-v1
by biohubesm3-sm-open-v1 is trained on 2.78 billion natural proteins. With synthetic data augmentation, this led to 3.15 billion protein sequences, 236 million protein structures, and 539 million proteins with function annotations, totaling 771 billion tokens.
Edoardo-BS/HuBERT-ECG-SFT-CardioLearning-large
by Edoardo-BSOriginal code at (https://github.com/Edoar-do/HuBERT-ECG)
Edoardo-Coppola/HuBERT-ECG-SFT-CardioLearning-large
by Edoardo-CoppolaOriginal code at (https://github.com/Edoar-do/HuBERT-ECG)
Original code at https://github.com/Edoar-do/HuBERT-ECG
Original code at https://github.com/Edoar-do/HuBERT-ECG
Original code at https://github.com/Edoar-do/HuBERT-ECG
genzeonplatform/cliniguard-vitals-ner
by genzeonplatformCliniGuard Vitals NER is a transformer-based clinical Named Entity Recognition model developed by Genzeon Platforms for automated extraction of vital signs, body measurements, and physiological parameters from clinical text.
genzeonplatform/cliniguard-ner
by genzeonplatformCliniGuard NER is a clinical Named Entity Recognition model developed by Genzeon Platforms for automated detection and de-identification of Protected Health Information (PHI) and Personally Identifiable Information (PII) in clinical text.
This model card provides an overview of the intended use of the ESMC SAE models and examples of how to access them, but it does not have a specific model or model weights. To access each SAE model collection, use the links below:
This model card provides an overview of the intended use of the ESMC SAE models and examples of how to access them, but it does not have a specific model or model weights. To access each SAE model collection, use the links below:
biohub/esmc-600m-2024-12
by biohubThis set of model weights was released with the GitHub-compatible esm package format. The models here are kept for backwards compatibility, but we recommend you use the HuggingFace-compatible model weights at biohub/ESMC-6B (or biohub/ESMC-300M / biohub/ESMC-600M) instead.
A Chinese medical reasoning model fine-tuned from Qwen3.5-4B using a two-stage training pipeline: Supervised Fine-Tuning (SFT) for format alignment, followed by Group Sequence Policy Optimization (GSPO) with an LLM-as-Judge reward function.
PhysicsWallahAI/Aryabhata-2.0
by PhysicsWallahAIAryabhata 2 is a reasoning-focused language model developed by PhysicsWallah for competitive STEM examinations (JEE, NEET). It is obtained by post-training GPT-OSS-20B via reinforcement learning on a curated curriculum of Physics, Chemistry, Mathematics, and General Reasoning questions — achieving…
FINAL-Bench/Darwin-218B-Delphi
by FINAL-Bench> VIDRAFT FINAL-Bench — chemistry-specialized 218B MoE, served via the DELPHI 5-Phase inference cascade.
AIRI-Institute/genatator-pipeline
by AIRI-InstituteGENATATOR-PIPELINE is a Hugging Face pipeline for ab initio gene annotation from genomic DNA. It accepts a FASTA file, finds candidate transcript intervals, assigns transcript type, predicts exon and CDS structure, and writes a GFF3 annotation file.
HealthJudge is a domain-adapted helpfulness evaluator for health-related Community Notes. It is designed to judge whether a note provides helpful context for a potentially misleading social-media post, following the Community Notes helpfulness criteria.
## Model Description ProtGPT3-112M is a single-sequence autoregressive protein language model for protein sequence generation. It is the smallest model in the ProtGPT3 family, an open-source suite of promptable and aligned protein language models ranging from 112M to 10B parameters.
ProtGPT3-10B is a single-sequence autoregressive protein language model for protein sequence generation. It is the largest model in the ProtGPT3 family, an open-source suite of promptable and aligned protein language models ranging from 112M to 10B parameters.
poolside-laguna-hackathon/protein-ligand-design
by poolside-laguna-hackathon!Protein-ligand interaction header
pankajpandey-dev/Carbon-3B-GGUF
by pankajpandey-devGGUF quantizations of HuggingFaceBio/Carbon-3B — a generative DNA foundation model — for efficient inference with llama.cpp.
UCL-CSSB/PlasmidGPT
by UCL-CSSBA HuggingFace-compatible repackaging of PlasmidGPT (Shao, 2024) — a GPT-2-style decoder pretrained on 153k engineered plasmid sequences from Addgene. Loadable with standard AutoModelForCausalLM and AutoTokenizer. Used as the base for PlasmidGPT-SFT and PlasmidGPT-GRPO.
monaaaaaa/MS2-SMILES-AlignNet
by monaaaaaa1. 概述 2. 数据处理流程 3. 模型架构 4. 损失函数设计 5. 训练流程 6. 配置参数
Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understanding
Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understanding
Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understanding
For a convenient overview and download list, visit our model page for this model.
akhljndl/smollm
by akhljndlA 53K-parameter weight-shared transformer that learns SMILES grammar by applying one small block 8 times. It reaches 95.3% validity on ZINC-250K — outperforming an unshared GPT 10× larger (87.6%).
biohub/esmc-300m-2024-12
by biohubThis set of model weights was released with the GitHub-compatible esm package format. The models here are kept for backwards compatibility, but we recommend you use the HuggingFace-compatible model weights at biohub/ESMC-6B (or biohub/ESMC-300M / biohub/ESMC-600M) instead.
ScientaLab/eva-rna
by ScientaLabaasatorres/esm2-sae-topk-16384-k512
by aasatorresSparse Autoencoder (SAE) trained on residue-level embeddings from ESM-2 (650M, layer 33) for interpretability research on protein language models.