mradermacher/Phi-4-Instruct-Bioaligned-GGUF

For a convenient overview and download list, visit our model page for this model.

A merged (ready-to-use) version of microsoft/phi-4 fine-tuned for biological R&D reasoning via QLoRA and evaluated on the Bioalignment Benchmark.

For a convenient overview and download list, visit our model page for this model.

PPTStab: Prediction and Designing of thermostable proteins with a desired melting temperature

This set of model weights was released with the GitHub-compatible esm package format. The models here are kept for backwards compatibility, but we recommend you use the HuggingFace-compatible model weights at biohub/ESMC-6B (or biohub/ESMC-300M / biohub/ESMC-600M) instead.

esm3-sm-open-v1 is trained on 2.78 billion natural proteins. With synthetic data augmentation, this led to 3.15 billion protein sequences, 236 million protein structures, and 539 million proteins with function annotations, totaling 771 billion tokens.