Find open-source science resources

A directory of tools, AI models, datasets, and research resources for biotech, bioinformatics, and other scientific fields. Aggregated from curated GitHub awesome-lists, HuggingFace, bio.tools, Bioconductor, and more.

526 of 6,590 resources

Showing 501526

Generative pre-training for genomics

Stale3212 years ago
Jupyter Notebook

Google DeepMind's AlphaFold-derived classifier for proteome-wide missense variant effect prediction, providing pathogenicity scores for all ~71M possible human missense variants and classifying 89% with 90% precision; pre-computed predictions are integrated into Ensembl VEP and UCSC Genome Browser to support clinical variant interpretation (Science 2023)

Archived6352 years ago
Python
Apache-2.0

Open language model for mathematics (7B/34B) trained on Proof-Pile-2, outperforming Minerva at equal scale on MATH benchmark, with tool use and formal theorem proving in Lean without finetuning (EleutherAI, ICLR 2024)

Stale1.1K2 years ago
Python
MIT

Extract figures, tables, captions, and section titles from scholarly PDFs

Stale7512 years ago
Scala
Apache-2.0

Protein structure prediction from ESM models

Archived4.2K2 years ago
Python
MIT

First system to make novel, verifiable scientific discoveries by pairing LLMs with evolutionary search, solving open problems in combinatorics (cap set problem) and discovering faster matrix multiplication algorithms

Stale1.1K2 years ago
Jupyter Notebook
Apache-2.0

Huawei's 3D high-resolution global weather forecast model at 0.25° resolution, first AI method to comprehensively outperform traditional NWP across all variables and lead times, integrated into ECMWF operational forecasts (Nature 2023)

Stale1.4K2 years ago
Python

3D Equivariant Diffusion for Target-Aware Molecule Generation (ICLR2023)

Stale3442 years ago
Python

Physics-informed ML and SciML

Stale882 years ago
MIT

Single-cell BERT for gene expression

Stale3592 years ago
Python
GPL-3.0

Weather prediction benchmark

Stale8322 years ago
Jupyter Notebook
MIT

Secure text-to-visualization through standardized chart specifications

Stale2812 years ago
Python
MIT

First foundation model for weather and climate by Microsoft, Vision Transformer-based architecture trained on heterogeneous datasets (ICML 2023)

Stale7012 years ago
Python
MIT

First vision-and-language foundation model for pathology AI, fine-tuned from CLIP on 249K image-caption pairs, enabling open-ended visual-semantic search and zero-shot diagnosis across histopathology (Pathology Foundation, 376+ stars)

Stale3822 years ago
Python

Large language model for science

Stale2.7K3 years ago
Jupyter Notebook
Apache-2.0

Learning nonlinear operators

Stale8314 years ago
Python
NOASSERTION

AI for chemical reaction prediction and synthesis planning

Stale4284 years ago
Python
NOASSERTION

Spherical CNNs for astronomy

Stale1694 years ago
Python
MIT

Crystal property prediction

Stale8854 years ago
Python
MIT

Deep learning system for de novo design of high-affinity protein binders, achieving strong binding across diverse target classes including challenging intracellular proteins with significantly higher success rates than traditional wet-lab screening methods (Google DeepMind, Nature 2024)

Multimodal generative AI assistant for computational pathology enabling interactive visual-language conversations over histopathology images for diagnostic reasoning, case discussion, and education, built on a Mistral-7B backbone with domain-specific fine-tuning (Mahmood Lab, Harvard Medical School, 1.2K+ stars)

Google DeepMind and Google Quantum AI's transformer-based neural-network decoder for quantum error correction, trained on real Sycamore quantum processor data to outperform tensor-network and correlated matching decoders at code distances 3 and 5, demonstrating ML's role in enabling fault-tolerant quantum computing (Nature 2024)

Ecological modeling and conservation AI

AI scientist framework for autonomous deep research in biological sciences, combining literature analysis agents with data scientist agents to enable iterative scientific discovery through user feedback integration; achieves state-of-the-art performance on BixBench benchmark (48.78% open-answer, 64.39% multiple-choice) outperforming Kepler and GPT-5 (bio-xyz, arXiv 2601.12542, 160+ stars, 2025-2026)