Find open-source science resources

A directory of tools, AI models, datasets, and research resources for biotech, bioinformatics, and other scientific fields. Aggregated from curated GitHub awesome-lists, HuggingFace, bio.tools, Bioconductor, and more.

229 of 7,055 resources

Showing 51–100

!chronos_logo1

Active5362 months ago
Python

This repository contains a 4-bit GPTQ quantized version of google/medgemma-27b-text-it, optimized for high-throughput inference using vLLM and the Marlin kernel.

Active3463 months ago

# DrugGen 2: A disease-aware language model for enhancing drug discovery DrugGen-2 is a disease‑aware language model specialized for generating drug-like SMILES structures based on both disease pathways and protein sequence.

Active6803 months ago
Python

CENO-P-1B is the multi-species alignment (MSA) post-trained variant of the 1B CENO DNA foundation model, for variant effect prediction (VEP). It carries intraencodingpattern in its config and ships the MSA scoring path (modelingcenop.py), which consumes a per-token seq_idx to score packed MSA…

Active4563 months ago
Python

CENO-1B-131k is the long-context (131k) checkpoint of the 1B CENO DNA foundation model — a causal language model over genomic sequence built on a Nemotron-H Mamba / Attention / Mixture-of-Experts hybrid backbone (no MSA inputs).

Active4523 months ago
Python

CENO-80M-1m is the long-context (1M) checkpoint of the 80M CENO DNA foundation model — a causal language model over genomic sequence built on a Nemotron-H Mamba / Attention / Mixture-of-Experts hybrid backbone (no MSA inputs).

Active3943 months ago
Python

A 1.7B-parameter causal language model distilled from Qwen3-30B-A3B on 6,122 STEM chain-of-thought samples using discrepancy-informed knowledge distillation. The training objective emphasizes proof structure, detects reasoning pivot tokens through token-level divergence dynamics, smooths…

Active1.4K3 months ago
Python

> NEXUS domain specialist for medical Q&A and clinical reasoning — lightweight & uncensored.

Active16.4K3 months ago

> NEXUS domain specialist for medical Q&A and clinical reasoning — lightweight & uncensored.

Active1.6K3 months ago
Python

!Screenshot 2026-07-05 at 2.33.47 AM

Active1.1K3 months ago
Python
Active03 months ago

Heretic-abliterated version of Qwen/Qwen2.5-0.5B-Instruct for the Evolva drug discovery pipeline.

Active2353 months ago
Python

Xinghe1-9B (杏核) is a specialized large language model fine-tuned for the formalization, computational derivation, and clinical reasoning of Huangdi Neijing. It is based on the Qwen3.5-9B-Instruct architecture and trained using the V3 Double-Purity SFT dataset.

Active463 months ago
Python

This repository contains Chemistry fine-tuned Qwen3-4B checkpoints from the local SciKnowEval-style generalization setup.

Active863 months ago
Python

👋 Join our LiGHT community. 📖 Check out the MeditronFO blog and MeditronFO preprint. 🔜 If you are a clinician join the MOOVE initiative here.

Active3703 months ago
Python

Sexo-FR is a French-language conversational language model that provides reliable, caring, and evidence-based sexual health information (information en santé sexuelle). It is part of a French public-health initiative whose goal is to make trustworthy sexual-health information more accessible to the…

Active373 months ago
Python

👋 Join our LiGHT community. 📖 Check out the MeditronFO blog and MeditronFO preprint. 🔜 If you are a clinician join the MOOVE initiative here.

Active6163 months ago
Python

Gravity-bio-16B-A3B is a biology-focus midtrained model derived from Gravity-16B-A3B-Base. It uses the same sparse Mixture-of-Experts (MoE) architecture and tokenizer as Gravity-16B-A3B-Base, with additional midtraining for biological understanding on TheBioCollection corpus.

Active2353 months ago
Python
Active3803 months ago
Python

Molexar-10M Base is the unconditional base model for Molexar, a unified multimodal molecular foundation model for drug design. It is trained as an autoregressive molecular language model over Fragment-SELFIES, a BRICS-fragment molecular language with validity-preserving decoding and…

Active153 months ago
Python

Molexar-10M Omni is the universal multi-condition model for Molexar, a unified multimodal molecular foundation model for drug design. It starts from fairydance/molexar-10m-base and is supervised fine-tuned to generate Fragment-SELFIES molecules under scalar molecular-property,…

Active113 months ago
Python

GRamma-12B is a 12-billion-parameter instruction-tuned language model specialized for the Greek medical domain. It is built on top of Gemma 3 12B Instruct and adapted through parameter-efficient fine-tuning on a collection of Greek and bilingual medical question-answering data.

Active193 months ago
Python

QLoRA adapter for Llama-3.1-8B-Instruct, fine-tuned on PubMedQA for yes / no / maybe biomedical question answering (run5).

Active213 months ago
Python

BioMatrix is a multimodal biological foundation model that natively integrates 1D sequences, 3D structures, and natural language for both molecules and proteins within a single decoder-only architecture.

Active1063 months ago
Python

A domain-adapted clinical LLM fine-tuned on synthetic Indian medical Q&A records using QLoRA (4-bit quantization) with Unsloth 2x speedup. Built to power the conversational AI layer.

Active853 months ago
Python

ProtGPT3-MSA is a multiple-sequence, homolog-conditioned autoregressive protein language model. It is part of the ProtGPT3 family, an open-source suite of promptable and aligned protein language models for protein sequence generation.

Active1.6K3 months ago
Python
Active83 months ago
Python

KAU-BioMedLLM is a research prototype for source-grounded biomedical variant interpretation. The current public release contains the LoRA adapter and documentation for a guarded report-generation system built around a curated biomedical evidence panel, citation enforcement, and abstention when…

Active03 months ago
Python

## Important Notice If you are using GENERator for sequence generation, please ensure that the length of each input sequence is a multiple of 6. This can be achieved by either: 1. Padding the sequence on the left with 'A' (left padding); 2. Truncating the sequence from the left (left truncation).

Active3.5K3 months ago
Python

Medical-GPT-OSS-Swallow-120B is a medical-domain language model based on tokyotech-llm/GPT-OSS-Swallow-120B-RL-v0.1. It is designed to support research and development toward safe and trustworthy AI for Japanese clinical settings.

Active153 months ago
Python

Medical-Qwen3-Swallow-30B-A3B is a medical-domain language model based on tokyotech-llm/Qwen3-Swallow-30B-A3B-RL-v0.2. It is designed to support research and development toward safe and trustworthy AI for Japanese clinical settings.

Active2403 months ago
Python

qwen35-9b-medical is an Ollama/GGUF medical assistant profile based on Jackrong/Qwen3.5-9B-Claude-4.6-Opus-Reasoning-Distilled-v2-GGUF, distributed locally through the Ollama model kwangsuklee/Qwen3.5-9B.Q4KM-Claude-4.6-Opus-Reasoning-Distilled-v2.

Active763 months ago
C

For a convenient overview and download list, visit our model page for this model.

Active7064 months ago
Python

# Instruction For more information, visit our GitHub repository: https://github.com/medfound/medfound

Active9004 months ago

This repository contains GGUF files for gemma4-12b-bioinfo, a fine-tuned Gemma 4 12B model for bioinformatics and computational biology.

Active884 months ago
C

gemma4-12b-bioinfo is a fine-tuned Gemma 4 12B instruction model for bioinformatics, genomics, and computational biology question answering.

Active484 months ago
Python

modelid = "DuanYi/R3LMHepG2"

Active104 months ago
Python

*GenerRNA is a generative pre-trained language model for de novo RNA sequence design. It is a Transformer (decoder-only, GPT-style) model that learns the "language" of RNA from millions of natural sequences and can generate novel, realistic RNA sequences without any structural input, functional…

Active04 months ago
Active124 months ago
Python

![Language: English]()

Active1.3K4 months ago
Python

Aryabhata 2 is a reasoning-focused language model developed by PhysicsWallah for competitive STEM examinations (JEE, NEET). It is obtained by post-training GPT-OSS-20B via reinforcement learning on a curated curriculum of Physics, Chemistry, Mathematics, and General Reasoning questions — achieving…

Active1974 months ago

> VIDRAFT FINAL-Bench — chemistry-specialized 218B MoE, served via the DELPHI 5-Phase inference cascade.

Active634 months ago
Python

HealthJudge is a domain-adapted helpfulness evaluator for health-related Community Notes. It is designed to judge whether a note provides helpful context for a potentially misleading social-media post, following the Community Notes helpfulness criteria.

Active314 months ago
Python

## Model Description ProtGPT3-112M is a single-sequence autoregressive protein language model for protein sequence generation. It is the smallest model in the ProtGPT3 family, an open-source suite of promptable and aligned protein language models ranging from 112M to 10B parameters.

Active2.6K4 months ago
Python

ProtGPT3-10B is a single-sequence autoregressive protein language model for protein sequence generation. It is the largest model in the ProtGPT3 family, an open-source suite of promptable and aligned protein language models ranging from 112M to 10B parameters.

Active994 months ago
Python

!Protein-ligand interaction header

Active64 months ago
Python

GGUF quantizations of HuggingFaceBio/Carbon-3B — a generative DNA foundation model — for efficient inference with llama.cpp.

Active6204 months ago

A HuggingFace-compatible repackaging of PlasmidGPT (Shao, 2024) — a GPT-2-style decoder pretrained on 153k engineered plasmid sequences from Addgene. Loadable with standard AutoModelForCausalLM and AutoTokenizer. Used as the base for PlasmidGPT-SFT and PlasmidGPT-GRPO.

Active1024 months ago
Python

Target-Conditioned Molecular Ideation Model for Drug Discovery Research

Active04 months ago
Python