RConci/GENESIS

Back to basics: Observed statistics are sufficient to predict drug responses

A diffusion language model for genome-scale perturbation prediction across diverse cellular contexts.

ScVI is a variational inference model for single-cell RNA-seq data that can learn an underlying latent space, integrate technical batches and impute dropouts. The learned low-dimensional latent representation of the data can be used for visualization and clustering.

CondSCVI is a variational inference model for single-cell RNA-seq data that can learn an underlying latent space. The predictions of the model are meant to be afterward used for deconvolution of a second spatial transcriptomics dataset in DestVI.

An Ontix autoencoder with an explainable, 16-dimensional latent space, trained on single-cell RNA-seq data. Each latent dimension is constrained by a gene ontology term generated with Claude Opus 5, making the embedding directly interpretable in terms of biological processes.