Find open-source science resources

Local-first, open-source AI workbench for scientists — an open alternative to Claude Science (by ai4s-research, maintainers of this list; TypeScript, MIT, 2026)

Multi-type data labeling and annotation tool

edfcore is a zero-dependency TypeScript library for reading EDF, EDF+, BDF, and BDF+ physiological recordings in browser and Node.js applications. It provides programmatic access to biosignal samples, channel metadata, per-channel sampling rates, physical units, annotations, and discontinuous recording timelines.

Research agent system deeply integrated with Zotero supporting Agent Mode, skills, multi-model backends (OpenAI-compatible, Claude Code, WebChat, Codex), and MinerU PDF parsing for literature Q&A, summarization, figure inspection, and source comparison (1.3K+ stars, 2026)

Open-source 3D architectural editor with an AI design assistant; build floor plans with walls, doors, windows, and furniture using natural language, with real-time WebGPU-powered previews (TangSY, 59+ stars, MIT License, 2026)

Open-source, local-first, model-agnostic AI research workbench for reproducible scientific discovery; runs Python/R notebooks, searches the web, calls scientific data connectors, and produces inspectable reports, tables, and figures in a self-hosted desktop workspace (1.5K+ stars, Apache 2.0, 2026)

Curated, accuracy-first collection of benchmarks for evaluating LLMs on scientific reasoning and discovery across mathematics, physics, chemistry, materials science, biology, and agentic science (subinium, 29+ stars, MIT License, 2026)

A transparent, unit-aware calculator for the mathematical relationship between peptide mass, target concentration and solution volume. It normalizes mg, micrograms, mL and microlitres, shows the formula and includes a reference syringe visualization. Research-use-only software: it does not select a solvent, validate a laboratory method, calculate a dose or provide administration guidance.

Satellite-powered agricultural and land analytics platform combining Sentinel-2 imagery, Google Earth Engine processing, real-time weather data, soil science databases, and AI-driven crop planning into a unified web dashboard (145+ stars, AGPL-3.0, 2026)

Auto-generates clean, customizable academic CVs from open research data (OpenAlex, ORCID, Crossref, DataCite, Open Editors Plus). A single canonical CV object drives every output format (HTML, PDF, DOCX, LaTeX, Markdown); citations render through CSL; and the account holder is matched by persistent identifier (ORCID / OpenAlex ID) rather than name string. Free for individuals, open-source, and FAIR by design.

Visualization intermediate language that lets AI agents create expressive, polished charts from simple, human-editable specs, compiling the same input to 30+ chart types across Vega-Lite, ECharts, and Chart.js with an MCP server for agent integration (1.9K+ stars, MIT License, 2026)

AI-driven desktop workbench for computational materials science with an interactive 3D structure editor, natural-language CatBot assistant, visual DAG workflow engine, remote-cluster access, and HPC job submission for VASP, ORCA, CP2K, Quantum ESPRESSO, GPAW, DFTB+, SIESTA, and LAMMPS (172+ stars, AGPL-3.0, 2026)

An interactive structure/property explorer for materials and molecules.

Inflexa is an open-source, agentic orchestration platform for computational biology and translational medicine. It is designed to assist researchers in analyzing multi-omics, cheminformatics, and imaging data by reading published literature, designing multi-step analysis plans, and executing experiments with full reproducibility.

Free, open-source desktop AI research assistant that runs locally and turns natural-language requests into real data analysis, literature search, figure generation, and manuscript review; ships with 149 scientific skills, 326 workflow templates, and 229 databases across genomics, proteomics, drug discovery, and materials science, plus a living lab notebook, 60+ scientific file previews, and LaTeX editing (K-Dense-AI, 908+ stars, MIT License, 2026)

Open-source construction ERP with AI-powered cost matching, BOQ generation, and PDF/CAD/BIM takeoff; 42 regional catalogues, 21 languages, 71 modules (DataDrivenConstruction, 717+ stars, AGPL-3.0, 2026)

Open-source AI workbench for scientific research that automates the full research loop — literature review, hypothesis generation, code writing, experiment execution, database querying, and report writing — with 290+ skills, specialized research agents, and a browser-based workspace (1453+ stars, Apache 2.0, 2026)

PureJsImage is a free, open-source TypeScript library for decoding, inspecting, processing, and converting ordinary images and scientific rasters in Node.js and modern browsers. It provides explicit readers for microscopy, whole-slide pathology, medical imaging, electron microscopy, spectroscopy, hyperspectral, and multidimensional array formats. These include OME-TIFF, OME-Zarr, Aperio SVS, DICOM, NIfTI, MRC/CCP4, NRRD, DigitalMicrograph, EMD, ENVI, and FITS. Range-backed readers can request selected regions, tiles, volume planes, and metadata while preserving native numeric samples where supported. The default package has no runtime dependencies. Optional JPEG and PNG WebAssembly accelerators require explicit registration.

Standalone browser-based Gene Ontology network viewer for exploring, filtering, searching, and exporting GO term and gene annotation neighborhoods from locally preprocessed GO OBO and GAF data.

Offline-first scientific writing workspace powered by Claude, integrating LaTeX, Python, and 100+ scientific skills with local execution, Zotero integration, and privacy-focused design (2026)

First system progressively surpassing human SOTA on frontier AI tasks (183.7%, 1.9%, 7.9% improvements), month-long autonomous discovery with 20,000+ GPU hours

Self-evolving AI research colleague built on OpenClaw with 285+ runtime-adaptive skills across 28+ disciplines, persistent cross-session research memory, and zero-hallucination citation protocols; agent autonomously writes new SKILL.md files based on research patterns without redeployment (828+ stars, MIT License, 2026)

2D interactive visualization in Jupyter.

Classic open-source plugin for document Q&A and summarization within Zotero

Web application for LLM-assisted manuscript review and annotation

Point and click, cross platform suite for analysing and visualizing next-generation sequencing datasets.