Find open-source science resources

A directory of tools, AI models, datasets, and research resources for biotech, bioinformatics, and other scientific fields. Aggregated from curated GitHub awesome-lists, HuggingFace, bio.tools, Bioconductor, and more.

373 of 6,565 resources

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Active5361 month ago
Python

# DrugGen 2: A disease-aware language model for enhancing drug discovery DrugGen-2 is a disease‑aware language model specialized for generating drug-like SMILES structures based on both disease pathways and protein sequence.

Active6801 month ago
Python

CENO-P-1B is the multi-species alignment (MSA) post-trained variant of the 1B CENO DNA foundation model, for variant effect prediction (VEP). It carries intraencodingpattern in its config and ships the MSA scoring path (modelingcenop.py), which consumes a per-token seq_idx to score packed MSA…

Active4561 month ago
Python

CENO-1B-131k is the long-context (131k) checkpoint of the 1B CENO DNA foundation model — a causal language model over genomic sequence built on a Nemotron-H Mamba / Attention / Mixture-of-Experts hybrid backbone (no MSA inputs).

Active4521 month ago
Python

CENO-80M-1m is the long-context (1M) checkpoint of the 80M CENO DNA foundation model — a causal language model over genomic sequence built on a Nemotron-H Mamba / Attention / Mixture-of-Experts hybrid backbone (no MSA inputs).

Active3941 month ago
Python

💻 Github | 📄 Report (Coming soon...) | 🚀 Demo

Active2541 month ago
Python

!image

Active2.5K1 month ago
Python

A 1.7B-parameter causal language model distilled from Qwen3-30B-A3B on 6,122 STEM chain-of-thought samples using discrepancy-informed knowledge distillation. The training objective emphasizes proof structure, detects reasoning pivot tokens through token-level divergence dynamics, smooths…

Active1.4K1 month ago
Python

Fine-tuned ESM-2 650M with LoRA for predicting protein subcellular localization (10 classes).

Active181 month ago
Python

PhenoVisionL is a Vision Transformer (ViT-Large) model fine-tuned to detect leaf phenological states in plant photographs: green leaves, colored (senescent) leaves, and breaking leaf buds. It was trained on 165,988 iNaturalist records of deciduous woody plants using a two-stage semi-supervised…

Active391 month ago
Python

PhenoVision is a Vision Transformer (ViT-Large) model fine-tuned to detect flowers and fruits in plant photographs. It was trained on 1.5 million human-annotated iNaturalist images and has been used to generate over 30 million new phenology records across 119,000+ plant species, vastly expanding…

Active451 month ago
Python

> NEXUS domain specialist for medical Q&A and clinical reasoning — lightweight & uncensored.

Active1.6K1 month ago
Python
Active01 month ago
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Active7081 month ago
Python

!Screenshot 2026-07-05 at 2.33.47 AM

Active1.1K1 month ago
Python

This repository contains LoRA finetunes of DiffusionGemma (image-conditioned discrete-diffusion LLM) for radiology visual question answering, each paired with an autoregressive Gemma-4 finetune as a controlled baseline. It corresponds to the paper Discrete Diffusion Language Models for Interactive…

Active01 month ago
Python

🤗 Blog | 📄 Paper | 💻 Code | 🌐 FineMed | 🩺 DoctoBERT

Active4601 month ago
Python

Heretic-abliterated version of Qwen/Qwen2.5-0.5B-Instruct for the Evolva drug discovery pipeline.

Active2351 month ago
Python

HantaBERT fine-tunes DNABERT-2 on hantavirus RNA sequences for three simultaneous classification tasks: species/lineage, host, and geographic origin. A single forward pass produces predictions for all three tasks along with a 768-dimensional embedding suitable for phylogenetic visualization.

Active01 month ago
Python

For a convenient overview and download list, visit our model page for this model.

Active4261 month ago
Python

Xinghe1-9B (杏核) is a specialized large language model fine-tuned for the formalization, computational derivation, and clinical reasoning of Huangdi Neijing. It is based on the Qwen3.5-9B-Instruct architecture and trained using the V3 Double-Purity SFT dataset.

Active461 month ago
Python

# Overview This is the CellHermes model, based on the LLaMA-3.1-8B-instruct architecture developed by Meta, fine-tuned using single-cell RNA sequencing (scRNA-seq) datasets from CellxGene and PPI network from BioGRID. CellHermes is an innovative framework for adapting existing large language models…

Active841 month ago
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This repository contains Chemistry fine-tuned Qwen3-4B checkpoints from the local SciKnowEval-style generalization setup.

Active861 month ago
Python

PlantGeneAnn is a plant genome foundation model that enables the prediction of various plant genomic elements at single-nucleotide resolution. The model is built upon the PlantBiMoE architecture with a 1D U-Net segmentation head, specifically designed for automated plant genome annotation.

Active461 month ago
Python

👋 Join our LiGHT community. 📖 Check out the MeditronFO blog and MeditronFO preprint. 🔜 If you are a clinician join the MOOVE initiative here.

Active3701 month ago
Python

Sexo-FR is a French-language conversational language model that provides reliable, caring, and evidence-based sexual health information (information en santé sexuelle). It is part of a French public-health initiative whose goal is to make trustworthy sexual-health information more accessible to the…

Active301 month ago
Python

👋 Join our LiGHT community. 📖 Check out the MeditronFO blog and MeditronFO preprint. 🔜 If you are a clinician join the MOOVE initiative here.

Active6161 month ago
Python
Active1.7K1 month ago
Python

Jolia is a 3D CT foundation model that encodes images into vector representations program. It encodes a whole 3D CT volume into:

Active4041 month ago
Python

Molexar-10M Base is the unconditional base model for Molexar, a unified multimodal molecular foundation model for drug design. It is trained as an autoregressive molecular language model over Fragment-SELFIES, a BRICS-fragment molecular language with validity-preserving decoding and…

Active152 months ago
Python

Molexar-10M Omni is the universal multi-condition model for Molexar, a unified multimodal molecular foundation model for drug design. It starts from fairydance/molexar-10m-base and is supervised fine-tuned to generate Fragment-SELFIES molecules under scalar molecular-property,…

Active112 months ago
Python

GRamma-12B is a 12-billion-parameter instruction-tuned language model specialized for the Greek medical domain. It is built on top of Gemma 3 12B Instruct and adapted through parameter-efficient fine-tuning on a collection of Greek and bilingual medical question-answering data.

Active192 months ago
Python

Full weight-level fine-tuning of InstaDeepAI/nucleotide-transformer-v2-50m-multi-species for binary DNA sequence classification on two GenomicBenchmarks tasks. All parameters are updated rather than using LoRA or a frozen backbone, with a leakage-free train/validation/test protocol and multi-seed…

Active02 months ago
Python

QLoRA adapter for Llama-3.1-8B-Instruct, fine-tuned on PubMedQA for yes / no / maybe biomedical question answering (run5).

Active212 months ago
Python

BioMatrix is a multimodal biological foundation model that natively integrates 1D sequences, 3D structures, and natural language for both molecules and proteins within a single decoder-only architecture.

Active1062 months ago
Python

A domain-adapted clinical LLM fine-tuned on synthetic Indian medical Q&A records using QLoRA (4-bit quantization) with Unsloth 2x speedup. Built to power the conversational AI layer.

Active852 months ago
Python

ProtGPT3-MSA is a multiple-sequence, homolog-conditioned autoregressive protein language model. It is part of the ProtGPT3 family, an open-source suite of promptable and aligned protein language models for protein sequence generation.

Active1.6K2 months ago
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Active82 months ago
Python

KAU-BioMedLLM is a research prototype for source-grounded biomedical variant interpretation. The current public release contains the LoRA adapter and documentation for a guarded report-generation system built around a curated biomedical evidence panel, citation enforcement, and abstention when…

Active02 months ago
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This model is an NF4 (Normal Float 4-bit) quantized version of the base model InstaDeepAI/nucleotide-transformer-2.5b-multi-species. The checkpoint was quantized using the BitsAndBytes library with double quantization enabled and BF16 computation.

Active532 months ago
Python

## Important Notice If you are using GENERator for sequence generation, please ensure that the length of each input sequence is a multiple of 6. This can be achieved by either: 1. Padding the sequence on the left with 'A' (left padding); 2. Truncating the sequence from the left (left truncation).

Active3.5K2 months ago
Python

Medical-GPT-OSS-Swallow-120B is a medical-domain language model based on tokyotech-llm/GPT-OSS-Swallow-120B-RL-v0.1. It is designed to support research and development toward safe and trustworthy AI for Japanese clinical settings.

Active152 months ago
Python

Medical-Qwen3-Swallow-30B-A3B is a medical-domain language model based on tokyotech-llm/Qwen3-Swallow-30B-A3B-RL-v0.2. It is designed to support research and development toward safe and trustworthy AI for Japanese clinical settings.

Active2402 months ago
Python

For a convenient overview and download list, visit our model page for this model.

Active4012 months ago
Python

gemma4-12b-bioinfo is a fine-tuned Gemma 4 12B instruction model for bioinformatics, genomics, and computational biology question answering.

Active1612 months ago
Python

modelid = "DuanYi/R3LMHepG2"

Active102 months ago
Python

esm3-sm-open-v1 is trained on 2.78 billion natural proteins. With synthetic data augmentation, this led to 3.15 billion protein sequences, 236 million protein structures, and 539 million proteins with function annotations, totaling 771 billion tokens.

Active2.9K2 months ago
Python

Original code at (https://github.com/Edoar-do/HuBERT-ECG)

Active652 months ago
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