Topaz (Nature Communications 2019)
github.com/tbepler/topazDeep-learning particle-picking framework for cryo-electron microscopy using positive-unlabeled convolutional neural networks that detect protein particles in micrographs at competitive precision with far fewer labeled examples than fully supervised baselines, serving as the automated front end of cryo-EM structure determination pipelines and adopted alongside CryoSPARC/RELION workflows with pre-trained general models, micrograph denoising, and CPU/GPU inference (Bepler Lab, MIT, 222+ stars, GPL-3.0, actively maintained 2019-2026)
Sourced from
- GitHub — github.com/tbepler/topaz
- Awesome AI for Science — github.com/tbepler/topaz
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