SSCPE

The framework SSCPE.pl infers Maximum Likelihood (ML) phylogenetic trees adoping the Structure and Stability constrained model of protein evolution (SSCPE) [1] that predicts site-specific selective pressures by fitting only two global parameters for the whole protein: the selection strength Lambda_str for maintaining protein structure and Lambda_stab for maintaining the protein folding stability against unfolding and misfolding [5,6].