seqgendiff

> MEDIUM CONFIDENCE! | > CORRECT NAME OF TOOL COULD ALSO BE 'seqgendiff R' | Data-based RNA-seq Simulations by Binomial Thinning | RNA-Seq Generation/Modification for Simulation | Generates/modifies RNA-seq data for use in simulations. We provide a suite of functions that will add a known amount of signal to a real RNA-seq dataset. The advantage of using this approach over simulating under a theoretical distribution is that common/annoying aspects of the data are more preserved, giving a more realistic evaluation of your method. The main functions are select_counts(), thin_diff(), thin_lib(), thin_gene(), thin_2group(), thin_all(), and effective_cor(). See Gerard (2019) <doi:10.1101/758524> for details on the implemented methods