RUV-III-NB

ruvIIInb is an R package that removes unwanted variation from raw sequencing count data using Negative Binomial and/or Zero Inflated Negative Binomial model. Thus far, the package has been applied to remove unwanted variation from single-cell RNA-seq and shotgun metagenomics data. The package takes raw sequencing count as input and thus in principle can be applied to data from any sequencing platforms.