RUTH

RUTH: Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries. ruth is a software to perform robust unified Hardy-Weinberg Equilbrium (HWE) tests for sequence-based genotypes under population structure. 'ruth' (Robust Unified Test for HWE) uses information from genotypes and principal components to perform either a likelihood ratio test or a score test to estimate variants' deviation from HWE after adjusting for population structure.