PlasmidLab

PlasmidLab is a free desktop plasmid editor for Mac and Windows with an AI agent that designs cloning workflows from natural-language instructions. Open GenBank, FASTA and SnapGene .dna files, view circular and linear maps, find restriction sites, design primers, and plan restriction, Gibson, Golden Gate, Gateway, TA/TOPO cloning. A built-in AI agent can design a construct from a plain-language request ("put GFP into pET-28a with Gibson") and lays out every step on your own sequences so you can check it before ordering oligos. Files stay on your computer. The AI agent works with your own Claude, ChatGPT or other subscription, with a free trial of 10 AI runs without one.