PANOGA

Identification of SNP Targeted Pathways From Genome-wide Association Study (GWAS) Data. Abstract The identification of the variants that explain familial risk of a specific disease is important since it enables the development of genetic risk prediction tests, diagnosis tools and therapeutical applications. One possible reason of multifactorial diseases is the alterations in the activity of biological pathways, where a series of mutations occur in distinct genes. While each of these variations extends slightly the likelihood of having the disease, they work together to give birth to the perturbations in normal biological processes. We provide a protocol \(termed PANOGA, Pathway and Network Oriented GWAS \(Genome-wide association study) Analysis) to devise functionally important pathways through the identification of genes within these pathways, where these genes are targeted by single nucleotide polymorphisms \(SNPs) obtained from the GWAS analysis ||| HOMEPAGE BROKEN!