LiGIoNs

A Computational Method for the Detection and Classification of Ligand-Gated Ion Channels. LiGIoNs: Prediction of Ligand Gated Ion Channels. LiGIoNs is a profile Hidden Markov Model based method capable of predicting Ligand-Gated Ion Channels utilizing their special topological information. The method consists of a library of 35 pHMMs, built from the alignment of transmembrane segments of representative LGIC sequences. In addition, 14 Pfam pHMMs are used to further annotate and correctly classify unknown protein sequences into one of the 10 LGIC subfamilies