hRUV

Hierarchical approach to removal of unwanted variation for large-scale metabolomics data. hRUV is a package for normalisation of multiple batches of metabolomics data in a hierarchical strategy with use of samples replicates in a large-scale studies. The tool utilises 2 types of replicates: intra-batch and inter-batch replicates to estimate the unwatned variation within and between batches with RUV-III.