G4SNVHunter
G-quadruplexes (G4s) are unique nucleic acid secondary structures predominantly found in guanine-rich regions and have been shown to be involved in various biological regulatory processes. G4SNVHunter is an R package designed to rapidly identify genomic sequences with G4-forming propensity and to accurately screen user-provided single nucleotide variants—as well as other small-scale variants such as indels and MNVs—for their potential to destabilize these structures. This allows researchers to then screen these critical variants for deeper study, digging into how they might influence biological functions—think gene regulation, for instance—by impairing G4 formation propensity.
README
G4SNVHunter G4SNVHunter is an R package leveraging the G4Hunter algorithm to systematically identify single nucleotide variants (SNVs), along with other small-scale variants such as indels and MNVs, that have the potential to disrupt G-quadruplex (G4) formation propensity. Installation Option 1: Install from GitHub You can install the package directly from GitHub, To run the sample code in our vignette, set the dependencies parameter to TRUE, NOTE Your R version must be ≥ 4.3. If you are…
- Repository
- github.com/rongxinzh/g4snvhunter
Source attribution
- GitHub — github.com/rongxinzh/g4snvhunter
- Bioconductor — G4SNVHunter
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