DiffGR

DiffGR is a statistical method for detecting differential genomic regions at TAD level between two Hi-C contact maps. Briefly, DiffGR utilizes the stratum-adjusted correlation coefficient (SCC), which can effectively eliminate the genomic-distance effect in Hi-C data, to measure the similarity of local genomic regions between two contact matrices, and then applies a nonparametric permutation test on those SCC values to detect genomic regions.