Borzoi (Nature Genetics 2025)
github.com/calico/borzoiDeep convolutional-transformer genomic model predicting cell- and tissue-specific RNA-seq coverage directly from 524K-base DNA sequence at 32 bp resolution, unifying transcription, splicing, and polyadenylation regulation; scores non-coding variant effects across multiple regulatory layers, competitive with or outperforming specialized models (APARENT2, Pangolin) on QTL benchmarks, pretrained on 7,611 human + 2,608 mouse ENCODE/GTEx tracks with HuggingFace weights (Calico Life Sciences, 268+ stars, Apache 2.0, 2023-2026)
Sourced from
- GitHub — github.com/calico/borzoi
- Awesome AI for Science — github.com/calico/borzoi
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