Assembline

Assembline is a multi-step protocol for integrative structural modeling of macromolecular complexes based on electron microscopy, cross-linking mass spectrometry and other data. The protocols is based on our Xlink Analyzer and external software: Integrative Modeling Plafform (IMP), Python Modeling Interface (PMI), UCSF Chimera, and imp-sampcon. Comparing to other methods, Assembline enables efficient sampling of conformational space through a multi-step procedure, provides new modeling restraints, and includes a unique configuration system for setting up the modelling project.