Find open-source science resources

A directory of tools, AI models, datasets, and research resources for biotech, bioinformatics, and other scientific fields. Aggregated from curated GitHub awesome-lists, HuggingFace, bio.tools, Bioconductor, and more.

881 of 7,064 resources

Showing 251–300

Heretic-abliterated version of Qwen/Qwen2.5-0.5B-Instruct for the Evolva drug discovery pipeline.

Active2353 months ago
Python

HantaBERT fine-tunes DNABERT-2 on hantavirus RNA sequences for three simultaneous classification tasks: species/lineage, host, and geographic origin. A single forward pass produces predictions for all three tasks along with a 768-dimensional embedding suitable for phylogenetic visualization.

Active03 months ago
Python

For a convenient overview and download list, visit our model page for this model.

Active4263 months ago
Python

Xinghe1-9B (杏核) is a specialized large language model fine-tuned for the formalization, computational derivation, and clinical reasoning of Huangdi Neijing. It is based on the Qwen3.5-9B-Instruct architecture and trained using the V3 Double-Purity SFT dataset.

Active463 months ago
Python

Pretrained LDARNet (~2M params) with learnable DNA tokenization (dynamic chunking + BiMamba-2).

Active03 months ago

Pretrained LDARNet (~110M params) with learnable DNA tokenization (dynamic chunking + BiMamba-2).

Active03 months ago

# Overview This is the CellHermes model, based on the LLaMA-3.1-8B-instruct architecture developed by Meta, fine-tuned using single-cell RNA sequencing (scRNA-seq) datasets from CellxGene and PPI network from BioGRID. CellHermes is an innovative framework for adapting existing large language models…

Active773 months ago
Python

This repository contains Chemistry fine-tuned Qwen3-4B checkpoints from the local SciKnowEval-style generalization setup.

Active863 months ago
Python

PlantGeneAnn is a plant genome foundation model that enables the prediction of various plant genomic elements at single-nucleotide resolution. The model is built upon the PlantBiMoE architecture with a 1D U-Net segmentation head, specifically designed for automated plant genome annotation.

Active923 months ago
Python

33 lightweight, standalone models that predict discrete Alzheimer's-disease–related phenotypes (e.g. medication use, APOE genotype, vascular pathology, sex) from SomaScan plasma proteomics. The full list is in phenotypes.tsv.

Active03 months ago

69 lightweight, standalone models that predict continuous Alzheimer's-disease–related phenotypes (cognition, neuropathology burden, motor/functional measures, demographics, a genetic risk score, and longitudinal change) from SomaScan plasma proteomics.

Active03 months ago

This repository contains a drop-in, Hugging Face–compatible checkpoint converted from https://huggingface.co/microsoft/llava-med-v1.5-mistral-7b. You can load it with the exact same code you use for the original model—no extra conversion steps required.

Active1.9K3 months ago

👋 Join our LiGHT community. 📖 Check out the MeditronFO blog and MeditronFO preprint. 🔜 If you are a clinician join the MOOVE initiative here.

Active3703 months ago
Python

Sexo-FR is a French-language conversational language model that provides reliable, caring, and evidence-based sexual health information (information en santé sexuelle). It is part of a French public-health initiative whose goal is to make trustworthy sexual-health information more accessible to the…

Active373 months ago
Python

👋 Join our LiGHT community. 📖 Check out the MeditronFO blog and MeditronFO preprint. 🔜 If you are a clinician join the MOOVE initiative here.

Active6163 months ago
Python

Gravity-bio-16B-A3B is a biology-focus midtrained model derived from Gravity-16B-A3B-Base. It uses the same sparse Mixture-of-Experts (MoE) architecture and tokenizer as Gravity-16B-A3B-Base, with additional midtraining for biological understanding on TheBioCollection corpus.

Active2353 months ago
Python

A lightweight plasma-protein aging clock that predicts chronological age from 85 unique inflammatory proteins measured by SomaScan (125 aptamers / SomaScan features). The model is a TabM† student distilled from a TabPFN v2 teacher, so it runs at inference without any TabPFN dependency (small,…

Active03 months ago

A lightweight plasma-protein aging clock that predicts chronological age from 92 Olink Inflammation-panel proteins. The model is a TabM† student distilled from a TabPFN v2 teacher, so it runs at inference without any TabPFN dependency (small, DUA-friendly artifacts).

Active03 months ago
Active3803 months ago
Python

Jolia is a 3D CT foundation model that encodes images into vector representations program. It encodes a whole 3D CT volume into:

Active4043 months ago
Python

Molexar-10M Base is the unconditional base model for Molexar, a unified multimodal molecular foundation model for drug design. It is trained as an autoregressive molecular language model over Fragment-SELFIES, a BRICS-fragment molecular language with validity-preserving decoding and…

Active153 months ago
Python

Molexar-10M Omni is the universal multi-condition model for Molexar, a unified multimodal molecular foundation model for drug design. It starts from fairydance/molexar-10m-base and is supervised fine-tuned to generate Fragment-SELFIES molecules under scalar molecular-property,…

Active113 months ago
Python

JEPA-based spatial-transcriptomics foundation model (TERRA). Code & docs: https://github.com/Lotfollahi-lab/terra

Active03 months ago

GRamma-12B is a 12-billion-parameter instruction-tuned language model specialized for the Greek medical domain. It is built on top of Gemma 3 12B Instruct and adapted through parameter-efficient fine-tuning on a collection of Greek and bilingual medical question-answering data.

Active193 months ago
Python

Full weight-level fine-tuning of InstaDeepAI/nucleotide-transformer-v2-50m-multi-species for binary DNA sequence classification on two GenomicBenchmarks tasks. All parameters are updated rather than using LoRA or a frozen backbone, with a leakage-free train/validation/test protocol and multi-seed…

Active03 months ago
Python

> Source code, training scripts, and inference utilities for this model: > github.com/NVIDIA-BioNeMo/KERMT > (v2.0 branch / v2.0.0 release tag)

Active03 months ago

QLoRA adapter for Llama-3.1-8B-Instruct, fine-tuned on PubMedQA for yes / no / maybe biomedical question answering (run5).

Active213 months ago
Python

BioMatrix is a multimodal biological foundation model that natively integrates 1D sequences, 3D structures, and natural language for both molecules and proteins within a single decoder-only architecture.

Active1063 months ago
Python

A domain-adapted clinical LLM fine-tuned on synthetic Indian medical Q&A records using QLoRA (4-bit quantization) with Unsloth 2x speedup. Built to power the conversational AI layer.

Active853 months ago
Python

This Hugging Face repository stores the official resources for RAMER (reaction-aware multimodal enzyme function representation model).

Active03 months ago

ProtGPT3-MSA is a multiple-sequence, homolog-conditioned autoregressive protein language model. It is part of the ProtGPT3 family, an open-source suite of promptable and aligned protein language models for protein sequence generation.

Active1.6K3 months ago
Python
Active83 months ago
Python

KAU-BioMedLLM is a research prototype for source-grounded biomedical variant interpretation. The current public release contains the LoRA adapter and documentation for a guarded report-generation system built around a curated biomedical evidence panel, citation enforcement, and abstention when…

Active03 months ago
Python

Stack is a large-scale encoder-decoder foundation model for single-cell biology. It introduces a novel tabular attention architecture that enables both intra- and inter-cellular information flow, setting cell-by-gene matrix chunks as the basic input data unit.

Active03 months ago

ApeTokenizer-SMILES is an Atom Pair Encoding (APE) tokenizer for SMILES strings, trained on ~2M unique canonical SMILES from ChEMBL 36. It is the SMILES counterpart to ApeTokenizer-SELFIES, released alongside ModernMolBERT.

Active03 months ago
Python

This model is an NF4 (Normal Float 4-bit) quantized version of the base model InstaDeepAI/nucleotide-transformer-2.5b-multi-species. The checkpoint was quantized using the BitsAndBytes library with double quantization enabled and BF16 computation.

Active533 months ago
Python
Active293 months ago

> [!WARNING] > This is a model trained on publicly available data. While we've done our best to curate the data, the model performance can still improve. Proceed with caution.

Active233 months ago

## Important Notice If you are using GENERator for sequence generation, please ensure that the length of each input sequence is a multiple of 6. This can be achieved by either: 1. Padding the sequence on the left with 'A' (left padding); 2. Truncating the sequence from the left (left truncation).

Active3.5K3 months ago
Python

 

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Active403 months ago

Back to basics: Observed statistics are sufficient to predict drug responses

Active983 months ago

!IntelliFold Cover

Active8.5K3 months ago

Medical-GPT-OSS-Swallow-120B is a medical-domain language model based on tokyotech-llm/GPT-OSS-Swallow-120B-RL-v0.1. It is designed to support research and development toward safe and trustworthy AI for Japanese clinical settings.

Active153 months ago
Python

Medical-Qwen3-Swallow-30B-A3B is a medical-domain language model based on tokyotech-llm/Qwen3-Swallow-30B-A3B-RL-v0.2. It is designed to support research and development toward safe and trustworthy AI for Japanese clinical settings.

Active2403 months ago
Python

!Pretrainloss

Active03 months ago

Mirror of the Boltz-2 structure- and affinity-prediction weights, packaged for use with tt-bio on Tenstorrent hardware. The files are byte-for-byte identical to the upstream Boltz-2 release; this repo simply hosts them on the Hugging Face Hub so tt-bio can fetch them with huggingface_hub like every…

Active03 months ago

This repository contains an MLX packaging of OpenMed/OpenMed-PII-ClinicalE5-Small-33M-v1 for Apple Silicon inference with OpenMed.

Active3053 months ago