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PureJsImage is a free, open-source TypeScript library for decoding, inspecting, processing, and converting ordinary images and scientific rasters in Node.js and modern browsers. It provides explicit readers for microscopy, whole-slide pathology, medical imaging, electron microscopy, spectroscopy, hyperspectral, and multidimensional array formats. These include OME-TIFF, OME-Zarr, Aperio SVS, DICOM, NIfTI, MRC/CCP4, NRRD, DigitalMicrograph, EMD, ENVI, and FITS. Range-backed readers can request selected regions, tiles, volume planes, and metadata while preserving native numeric samples where supported. The default package has no runtime dependencies. Optional JPEG and PNG WebAssembly accelerators require explicit registration.

Open-source 3D architectural editor with an AI design assistant; build floor plans with walls, doors, windows, and furniture using natural language, with real-time WebGPU-powered previews (TangSY, 59+ stars, MIT License, 2026)

Curated, accuracy-first collection of benchmarks for evaluating LLMs on scientific reasoning and discovery across mathematics, physics, chemistry, materials science, biology, and agentic science (subinium, 29+ stars, MIT License, 2026)

Offline-first scientific writing workspace powered by Claude, integrating LaTeX, Python, and 100+ scientific skills with local execution, Zotero integration, and privacy-focused design (2026)

Visualization intermediate language that lets AI agents create expressive, polished charts from simple, human-editable specs, compiling the same input to 30+ chart types across Vega-Lite, ECharts, and Chart.js with an MCP server for agent integration (1.9K+ stars, MIT License, 2026)

Free, open-source desktop AI research assistant that runs locally and turns natural-language requests into real data analysis, literature search, figure generation, and manuscript review; ships with 149 scientific skills, 326 workflow templates, and 229 databases across genomics, proteomics, drug discovery, and materials science, plus a living lab notebook, 60+ scientific file previews, and LaTeX editing (K-Dense-AI, 908+ stars, MIT License, 2026)

Self-evolving AI research colleague built on OpenClaw with 285+ runtime-adaptive skills across 28+ disciplines, persistent cross-session research memory, and zero-hallucination citation protocols; agent autonomously writes new SKILL.md files based on research patterns without redeployment (828+ stars, MIT License, 2026)

Standalone browser-based Gene Ontology network viewer for exploring, filtering, searching, and exporting GO term and gene annotation neighborhoods from locally preprocessed GO OBO and GAF data.

Web application for LLM-assisted manuscript review and annotation

edf2csv is a local command-line tool for converting EDF, EDF+, BDF, and BDF+ physiological recordings into CSV and JSON files. It exports signal values, channel information, annotations, and recording metadata while preserving original sampling rates, physical units, and discontinuities.