Find open-source science resources

A directory of tools, AI models, datasets, and research resources for biotech, bioinformatics, and other scientific fields. Aggregated from curated GitHub awesome-lists, HuggingFace, bio.tools, Bioconductor, and more.

10 of 5,923 resources

Deep probabilistic framework for single-cell and spatial omics analysis, integrating scVI, scANVI, totalVI and other VAE-based models for batch correction, cell annotation, multi-omics integration, and RNA velocity (scverse/NumFOCUS, Nature Methods 2018/2024)

Active1.6K2 days ago
Python
BSD-3-Clause

Python astronomy tools

Active5.2K3 days ago
Python
BSD-3-Clause

Official Jupyter extension with `%%ai` magic commands and sidebar chat assistant, connecting multiple model providers and local inference

Active4.3K1 week ago
Python
BSD-3-Clause

Deep learning software to decode EEG, ECG or MEG signals, providing standardized neural network models, preprocessing pipelines, and evaluation workflows for brain-computer interfaces and cognitive neuroscience research (1.2K+ stars, BSD 3-Clause, actively maintained)

Active1.2K1 week ago
Python
BSD-3-Clause

Fast, interactive, multi-dimensional image viewer for Python, foundational platform for scientific imaging AI with a rich plugin ecosystem integrating deep learning segmentation, object tracking, and microscopy analysis workflows (2.6K+ stars)

Active2.7K2 weeks ago
Python
BSD-3-Clause

Generalist deep learning algorithm for cell and nucleus segmentation across diverse image types, with human-in-the-loop training (2.0) and one-click image restoration (3.0), 70K+ training objects (Nature Methods 2021/2022/2025)

Active2.2K2 weeks ago
Python
BSD-3-Clause

Machine learning and statistical learning for neuroimaging in Python, providing easy-to-use tools for fMRI and MRI analysis including decoding, connectivity estimation, and parcellation with seamless scikit-learn integration (INRIA Parietal team, 1.4K+ stars)

Active1.4K2 weeks ago
Python
BSD-3-Clause

Probabilistic framework for inferring cell fate decisions and trajectory dynamics from multi-view single-cell data using Markov chains and machine learning, integrating RNA velocity, pseudotime, and metabolic labeling to predict differentiation paths and terminal states (scverse/Theis Lab, 449+ stars, BSD 3-Clause)

Active4501 month ago
Python
BSD-3-Clause

Deep learning-based variant caller

Active3.7K2 months ago
Python
BSD-3-Clause

Deep learning-based object detection and segmentation for star-convex shapes, widely adopted for cell and nucleus segmentation in fluorescence and electron microscopy via a compact neural network architecture with non-maximum suppression and shape-based post-processing (Nature Methods 2020, 1.2K+ stars)

Active1.2K3 months ago
Python
BSD-3-Clause