Find open-source science resources

DISCO (DIffusion for Sequence-structure CO-design) is a multimodal generative model that simultaneously co-designs protein sequences and 3D structures, conditioned on and co-folded with arbitrary biomolecules — including small-molecule ligands, DNA, and RNA.

A diffusion language model for genome-scale perturbation prediction across diverse cellular contexts.

A PyTorch port of AlphaGenome, the DNA sequence model from Google DeepMind that predicts hundreds of genomic tracks at single base-pair resolution from sequences up to 1M bp.

JAMUN is a novel approach for generating conformational ensembles of protein structures, presented in the paper JAMUN: Bridging Smoothed Molecular Dynamics and Score-Based Learning for Conformational Ensembles.